Higher Incidence of Metabolic Syndrome in Black Women With Polycystic Ovary Syndrome: A Longitudinal Study

Abstract

Context: Cross-sectional studies have identified an increased risk of metabolic syndrome (MetSyn) in women with polycystic ovary syndrome (PCOS), but longitudinal data are limited and primarily include White and European cohorts. Objective: To compare the longitudinal risk of MetSyn in Black and White women with PCOS and to identify potential factors mediating the risk of MetSyn. Methods: Longitudinal cohort study with a follow-up of 5.3 years at an academic medical center of: 247 adult women with hyperandrogenic PCOS phenotype with 2 or more visits at least 3 years apart. The main outcome measure was incidence of MetSyn in Black and White women with PCOS. Results: Using a mixed-effects model over time, the incidence of MetSyn was higher in Black women (45.9±4.74 per 100 person-years) than in White women (31.3±3.03 per 100 person-years) (P