Studies on the Agalwood (Jinkō). VII.1) Structures of Phenylethyl-chromone Derivatives AH7, AH8 and AH9

Abstract

Three new phenylethylchromone derivatives, tentatively named AH7, AH8 and AH9, were isolated from acetone and pyridine extracts of agalwood (jinko) from Kalimantan. AH7 from the pyridine extract was characterized as 5,8-dihydroxy-2-(2-phenylethyl)chromone, and AH8from the acetone extract was elucidated to be 6,7-dimethoxy-2-[2-(4-methoxyphenyl)ethyl]chromone. AH9, acetylated in order to separate it from the mixture, was concluded to be (5S,6S,7R)-5a’,6a,7a-triacetoxy-2-[2-(2-acetoxyphenyl)ethyl]-5,6,7,8,8-pentahydrochromone on the basis of the proton nuclear magnetic resonance 1H-NMR) spectrum, dihedral angle and circular dichroism (CD) spectral data. © 1988, The Pharmaceutical Society of Japan. All rights reserved.