Revolutionizing Drug Delivery: Unraveling the Nanostructural Marvels of Cubosomes and their Comprehensive Evaluation in Pharmaceutical Applications

Abstract

Cubosomes, recognized as innovative lipid-based drug delivery systems, share similarities with other nanosystems like liposomes and niosomes [1]. These nanostructures are liquid crystalline particles commonly crafted using specific amphiphilic lipids, such as glyceryl monophosphate and phytantriol, in the presence of an appropriate stabilizer [1]. Characterized by their unique three-dimensional organization, cubosomes manifest as curved bicontinuous lipid bilayers arranged in a honeycomb-like structure. In the realm of drug delivery, cubosomes offer a promising platform with distinct advantages. Their nanostructure, composed of carefully selected lipids, provides a tailored environment for drug encapsulation and controlled release. The amphiphilic nature of the lipids contributes to the stability and versatility of cubosomes as drug carriers[2].