Gluten and IgA nephropathy: You are what you eat?

Abstract

Although extensively studied, the relationship between dietary antigens - in particular, gluten - and IgA nephropathy remains unclear. Using a double transgenic mouse model of IgA nephropathy that expresses both human IgA1 and human CD89, Papista et al. report that a gluten-free diet protects against the development of IgA deposition and glomerular injury, and that these events occur with the introduction of dietary gluten.