PyFluor: A low-cost, stable, and selective deoxyfluorination reagent

Abstract

We report an inexpensive, thermally stable deoxyfluorination reagent that fluorinates a broad range of alcohols without substantial formation of elimination side products. This combination of selectivity, safety, and economic viability enables deoxyfluorination on preparatory scale. We employ the [ 18 F]-labeled reagent in the first example of a no-carrier-added deoxy-radiofluorination.