Diaminothiazoles modify tau phosphorylation and improve the tauopathy in mouse models

Abstract

Background: Tau is hyperphosphorylated in the tauopathies. Targeting Tau kinases CDK5 and GSK3β represents a potential therapeutic approach. Results: Inhibitors of Tau kinases are neuroprotective, decrease PHF-1 immunoreactivity, and induce recovery of memory by fear conditioning. Conclusion: Diaminothiazoles as CDK5 and GSK3β inhibitors improve the tauopathy in mouse models. Significance: Dual kinase inhibition can be critical for efficacy when treating tauopathies. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.