Deep Eutectic Solvent as a Sustainable Medium for C-C Bond Formation Via Multicomponent Radical Conjugate Additions

Abstract

Deep eutectic solvents (DESs) have been used for the first time as a sustainable medium in radical-mediated molecular organic synthetic protocols. This study reports an efficient protocol for the C-C bond formation through radical conjugate addition of simple olefins (di-and trisubstituted). An inexpensive and abundant iron catalyst [Fe(acac)3] together with nontoxic silane (poly(methylhydrosiloxane) (PMHS)) was employed, using choline chloride/ethylene glycol (1:2) as a solvent under air and mild reaction conditions. Different functional groups were well tolerated, and also, the reaction could be carried out on a gram scale with excellent yields.