Histone deacetylases (HDACs) modify smooth muscle cell (SMC) proliferation and affect neointimal lesion formation by regulating cell cycle progression. HDACs might also regulate SMC differentiation, although this is not as well characterized.
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Tang, Y., Boucher, J. M., & Liaw, L. (2012). Histone Deacetylase Activity Selectively Regulates Notch‐Mediated Smooth Muscle Differentiation in Human Vascular Cells. Journal of the American Heart Association, 1(3). https://doi.org/10.1161/jaha.112.000901