Abstract
Stage‐specific embryonic antigen‐1 (SSEA‐1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody. Of 19 renal cell carcinoma (RCC) samples tested, 12 were positive for SSEA‐1; SSEA‐1 was also found on distinct elements in two samples of Wilms' tumor. No correlation was found between expression of SSEA‐1, and RCC morphology or pattern of growth. Because SSEA‐1 is found on proximal tubules in the normal kidney, these results support the hypothesis that RCC arises from the cells of the proximal tubule. Furthermore, since >60% of the RCCs examined expressed SSEA‐1, this antigen may prove to be a useful target for immunolocation or therapy of metastatic RCC. Copyright © 1987 American Cancer Society
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CITATION STYLE
Liebert, M., Jaffe, R., Taylor, R. J., Ballou, B. T., Solter, D., & Hakala, T. R. (1987). Detection of SSEA‐1 on human renal tumors. Cancer, 59(8), 1404–1408. https://doi.org/10.1002/1097-0142(19870415)59:8<1404::AID-CNCR2820590804>3.0.CO;2-D
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