Synthesis and characterization of newly synthesized Schiff base ligand and its metal complexes as potent anticancer

Abstract

2-((2-mercaptophenyl)imino)-1,2-diphenylethan-1-ol(H 2 L) Schiff base ligand from benzoin and 2-aminothiophenol was prepared and characterized. The Co(II),Cd(II),La(III), and Gd (III) complexes was prepared in bulk size and La(III) complex also prepared in nano size. The Schiff base and its complexes was characterized by elemental analysis, 1 HNMR, IR, Mass spectroscopy, UV-VIS spectra, thermal analysis, conductivity measurements, and magnetic moments. The selected analyses showed that the complexes are octahedral and non-electrolytic in nature and the azomethine nitrogen wasn't participated in complexation. The ability of the free ligand to remove different heavy metals was studied. The cytotoxicity effect of Cd(II) complex sing MTT method exhibited a significant nontoxic behavior and higher cell viability on Vero, Caco-2 and MCF-7 cells than the free ligand itself. The cytotoxicity results revealed that the Cd(II) complex could become safe to be used as anticancer agent for Vero, Caco-2 and MCF-7 cells. By examining its pharmacological activity, we were able to identify new potent and selective anticancer.