Ligand-controlled asymmetric arylation of aliphatic α-amino anion equivalents

Abstract

A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines. © 2014 American Chemical Society.