To Each (MHC Molecule) Its Own (Binding Motif)

Abstract

In the mid-1980s Townsend et al. ([1][1]) demonstrated that viral Ags recognized by class I restricted CTL could be mimicked by incubating target cells with short synthetic peptides representing viral sequences. Soon thereafter, Wiley and coworkers ([2][2]) published the structure of the HLA-A2.1