Regional cerebral blood flow during rest and skilled hand movements by Xenon-133 inhalation and emission computerized tomography

Abstract

Regional cerebral blood flow (CBF) was studied in 16 normal adult volunteers during rest and in 10 the study was repeated during skilled hand movements. A fast-rotating ('dynamic'), single-photon emission computerized tomograph (ECT) with four detector heads was used. Xenon-133 was inhaled over a 1-min period at a concentration of 10 mCi/L. The arrival and washout of the radioisotope was recorded during four 1-min periods. Two slices, 2 cm thick, 7 and 12 cm above the orbitomeatal line were obtained in every study. CBF averaged 60 ml/100/g/min (SD ± 11) in the lower slice and 51 ml/100/g/min (SD ± 13) in the upper slice. A symmetric pattern comparing right to left sides was found in both slices. Finger tapping and writing with the right hand increased CBF in specific areas of the upper slice: in the contralateral hand area by 35 ± 15% (p<0.025), and in the supplementary motor area on both sides by 34 ± 15% (p<0.025).