Open Genes-a new comprehensive database of human g enes associat ed with aging and long evity

Abstract

The Open Genes database was created to enhance and simplify the search for potential aging therapy targets. We collected data on 2402 genes associated with aging and de v eloped con v enient tools f or searching and comparing gene features. A comprehensiv e description of genes has been pro vided, including lifespan-e xtending interv entions, age-related changes, longe vity associations, gene e v olution, associations with diseases and hallmarks of aging, and functions of gene products. For each e xperiment, w e presented the necessary str uct ured data for e v aluating the experiment's quality and interpreting the study's findings. Our goal was to stay objective and precise while connecting a particular gene to human aging. We distinguished six types of studies and 12 criteria for adding genes to our database. Genes were classified according to the confidence le v el of the link between the gene and aging. All the data collected in a database are provided both by an API and a user interf ace. T he database is publicly a v ailable on a w ebsite at https:// open-genes.org/