Herbal formuLation of Azadirachta indica and Stevia rebaudiana and Its Anti-inflammatory and Anti-Diabetic Activity

Abstract

Introduction: Azadirachta indica, a natural herb also called Neem, and its seed extract has various medicinal uses. Neem also possesses notable insecticidal and pesticide activities. On the other hand, Stevia rebaudiana extract has alpha amylase glycosidase inhibitory activity, which contrasts with traditional wheat bread. This last plant can also regulate blood glucose levels, and prevent hypertension and caries. Aim: This study aimed to analyse the anti-diabetic and anti-inflammatory activities of Azadirachta indica and stevia rebaudiana. Materials and Methods: 2.5 g from Azadirachta indica and Stevia rebaudiana plants mixed with 100 mL of distilled water were boiled. The final extract was then filtered using Whatman filter paper. Spearman correlation analysis was done by SPSS. Positive correlation analysis level of significance was set as r=1. Results: The anti-diabetic activity and anti-inflammatory activities of Azadirachta indica and Stevia rebaudiana extracts showed positive spearman correlations (r = 1). Both activities happen in a dose-dependent manner, being higher with the increasing of the concentration and of the absorbance values. Conclusion: Through this study, it was possible to conclude that Azadirachta indica and Stevia rebaudiana have great anti-inflammatory and anti-diabetic activities and can be used as a possible alternative drug for attenuating inflammation and preventing diabetic complications.