Collagenous colitis

Abstract

We report a case of 76-year-old male with a complaint of watery diarrhea due to collagenous colitis. Biopsy specimens from the sigmoid colon showed a thick subepithelial collagen band, which were immunoreactive for collagen types 1, 3, 5 and 6. We started salazopyrine as the treatment of collagenous colitis but observed no effect, then changed to prednisolone 30mg per day. After the treatment with prednisolone, his symptoms had completely improved. The results of this case suggest that prednisolone may be useful and can lead to the complete remission in the treatment of collagenous colitis.