Illudin analogs as anti-tumor agents.

Abstract

Illudin S or illudin M analogs I or II (R1 = H, alkyl, alkoxy; R2 = alkyl; R3 = alc., ester) are administered to inhibit tumor cell growth. Dehydroilludin M (III) was prepd. by treatment of illudin M with pyridinium dichromate. The IC50 of III against HL-60 leukemia cells was 46 nm. III was effective at inhibiting tumor growth in mice. Structure-function studies of illudins and derivs. identified 3 crit. sites for illudin toxicity. [on SciFinder(R)]