Microbial modification of pradimicins at c-11 leading to 11-0-demethyl-and 11-0-l-xylosylpradimicins a and fa-1

Abstract

a screen of pradimicin-nonproducing mutants derived from Actinomadura verrucosospora subsp. neohibisca R103-3, we found a strain capable of producing 1 1-hydroxyl analogs ofpradimicins A and FA-1, designated pradimicins H and FH, respectively. Feeding of pradimicins H and FH to growing cultures of an actinomycete strain AA3798produced 1 1-O-L-xylosylpradimicins H and FH, respectively. These 1 1-O-L-xylosylpradimicins had a broad spe. © 1993, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.