Abstract
Mono- and dihydroxylated metabolites of thalidomide were efficiently prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. 5,N-Dihydroxythalidomide was a much more potent TNF-α production inhibitor than thalidomide. © 2006 Pharmaceutical Society of Japan.
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Nakamura, T., Noguchi, T., Kobayashi, H., Miyachi, H., & Hashimoto, Y. (2006). Mono- and dihydroxylated metabolites of thalidomide: Synthesis and TNF-α production-inhibitory activity. Chemical and Pharmaceutical Bulletin, 54(12), 1709–1714. https://doi.org/10.1248/cpb.54.1709
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