Preliminary Study of Clinical Antidiabetic Activity of Salam Leaves (Eugenia Polyantha) and Sambiloto Leaves (Andrographis Paniculata) in Type 2 Diabetic Patients

Abstract

Diabetes mellitus is one of disease with high prevalence in the world. Salam (Eugenia polyantha) and Sambiloto (Andrographis paniculata) are plant that widely used traditionally for medicine including to treat diabetes mellitus. Many studies have revealed that these herbs have bioactive compounds that contribute to antidiabetic properties. The objective of the present study is to analyze the clinical antidiabetic properties of Eugenia polyantha and Andrographis paniculata leaves in type 2 diabetic patients. Clinical test with before and after design was used as method. Sample was designed by consecutive sampling with inclusion and exclusion consideration. Total subject of this study are 40 peoples and were divided into two group. One group consumed Eugenia polyantha leaf and the other one consumed Andrographis paniculata leaf. 300 mg of these medicinal plants was given as capsule. The prescription was 1-2 capsule per day for one week. During this study we observed several parameters include: patients characteristic, blood glucose level, uric acid, total cholesterol, blood pressure and other subjective complaints. The result showed that among 20 respondents of each group, there are 70% and 80% respondents decreased fasting blood glucose level (<140 mg/dL) compared to before treatment with these herbs. It can be concluded that Andrographis paniculata and Eugenia polyantha leaf may have positive role in type 2 diabetic patients.