Updates in the Management of Myelofibrosis

Abstract

The JAK inhibitors ruxolitinib, fedratinib, and pacritinib have demonstrated significant activity in improving symptoms and spleen size, as well as quality of life, in patients with myelofibrosis. Additionally, the recent approval of another JAK inhibitor, momelotinib, for patients with myelofibrosis and anemia has further expanded the available treatment options for this malignancy. As research continues to reveal the best treatment strategies, clinical trials will remain an essential avenue for improving outcomes in this patient population.