Cerebrospinal fluid concentration of interleukin-6 and interleukin-10 in idiopathic intracranial hypertension

Abstract

The aim of investigation was to determine interleukin-6 (IL-6; a proinflammatory cytokine) and IL-10 (an anti-inflammatory cytokine) concentrations in cerebrospinal fluid (CSF) of Idiopathic Intracranial Hypertension patients (IIH). The study covered 28 middle aged female (IIH patients, n = 14; controls, n = 14). CSF IL-6 and IL-10 concentration were determined by the use of commercial enzyme-linked immunosorbent assay (ELISA) kits. Concentration of IL-6 and IL-10 in CSF of IIH patients was 23.6±3.46 pg mL-1 and 3.7±0.5 pg mL-1 and in controls was 1.8±1.9 and 4.0±1.0 pg mL-1, respectively. Elevated IL-6 concentration in IIH patients found to be statistically significant in comparison to controls (p<0.05). There was no significant difference of IL-10 in IIH and controls. Role of immune system and inflammatory processes in etiology and pathogenesis of IIH must be taking into account.