Evaluation of antihyperglycemic potential of homeopathic medicines Insulinum 6CH, Pancreatinum 6CH and Uranium nitricum 6CH in streptozotocin-induced diabetic Rats

Abstract

Introduction Diabetes Mellitus is an emerging endocrine and metabolic disorder which has affected millions of people globally. Homeopathic system of medicine uses ultra-molecular doses for treatment of Diabetes Mellitus. Homeopathic medicines are prepared from plant, mineral, sarcodes, nosodes and animal parts. Insulinum 6 CH, Pancreatinum 6 CH and Uranium nitricum 6 CH are used in homeopathy for treatment of Diabetes Mellitus. However, no preclinical studies have been investigated for the anti-diabetic effect and its safety. Methods Homeopathic medicines Insulinum 6CH, Pancreatinum 6CH and Uranium nitricum 6CH (1012) dilution factor were used to examine antihyperglycemic effects in streptozotocin induced diabetic rats. After 28 days of treatment, bodyweight, Hematology, Biochemistry (serum glucose, urea, creatinine, SGPT, SGOT, ALP, Triglyceride and HDL-cholesterol), Oral Glucose Tolerance Test, HbA1C with histopathology of (Liver, Kidney, Pancreas) were measured. Results After Streptozotocin induction, the animals have shown significant increase in the fasting blood glucose level (p<0.01) as compared to normal control animals. Treatment with homeopathic medicine Insulinum 6CH, Pancreatinum 6CH and Uranium nitricum 6CH potency showed significant decrease in levels of Glucose (p<0.05), OGTT, Total protein (P<0.001), ALP (P<0.05), Cholesterol (P<0.001), SGPT (P<0.001), SGOT (p<0.01), Urea, HbA1C as compared to diabetic animal. Conclusions In the present study homeopathic medicine Insulinum 6CH, Pancreatinum 6CH and Uranium nitricum 6CH potency exhibit antihyperglycemic effects in streptozotocin induced diabetic rats.