Comparison of the Effectiveness of Hepatoprotectors of Black Cumin Extract and Temulawak Extract in SGOT and SGPT Induced by Paracetamol

Abstract

ABSTRACT   Background: Paracetamol is used for analgesics and antipyretics, its use can damage the liver. Herbs that prevent liver disorders are curcuma. Black cumin can increase antioxidants. Objective: This study aims to compare the effectiveness of black cumin extract and curcuma against the liver function of paracetamol-induced rats. Methods: A laboratory experimental study posttest only with control group design. A total of 4 groups were treated for 7 days. SGOT and SGPT levels were tested. Data analysis using one-way ANOVA post hoc Games-Howell.Results: K- and K+ groups in this study showed an increase in SGOT SGPT levels. There is an effect of giving a dose of paracetamol 500 mg/kgBB on liver damage, there is no differences and significant effect in the administration of black cumin extract and curcuma dose 500 mg/kgBB to the liver of rats that have been induced by paracetamol (p>0.05). Conclusion: Giving paracetamol has an influence on rat liver damage. And there was no difference in the effects of hepatoprotector in groups given black cumin extract and curcuma in paracetamol-induced rats.   Keywords: black cumin, curcuma, paracetamol, SGOT, SGPT  ABSTRAK   Latar Belakang: Parasetamol digunakan untuk analgesik dan antipiretik, pemakaiannya yang berlebihan dapat merusak hepar. Herbal pencegah gangguan hepar adalah temulawak. Jintan hitam dapat meningkatkan antioksidan. Tujuan: Membandingkan efektivitas ekstrak jintan hitam dan temulawak terhadap fungsi hepar tikus yang diinduksi parasetamol. Metode: Penelitian eksperimental laboratorik posttest only with control group design. Sebanyak 4 kelompok diberi perlakuan selama 7 hari. Uji kadar SGOT dan SGPT dilakukan. Analisis data menggunakan one-way ANOVA post hoc Games-Howell. Hasil: Kelompok K- dan K+ pada penelitian ini menunjukkan peningkatan kadar SGOT SGPT. Terdapat pengaruh pemberian parasetamol dosis 500 mg/kgBB pada fungsi hepar, tidak terdapat perbedaan dan pengaruh signifikan pemberian ekstrak jintan hitam dan temulawak dosis 500 mg/kgBB terhadap hepar tikus yang telah diinduksi parasetamol (p>0,05). Kesimpulan: Pemberian parasetamol memiliki pengaruh terhadap kerusakan hepar tikus. Serta tidak adanya perbedaan efek hepatoprotektor pada kelompok yang diberikan ekstrak jintan hitam dan temulawak pada tikus yang diinduksi parasetamol.   Kata Kunci: jintan hitam, parasetamol, SGOT, SGPT, temulawak