Anti-Mycobacterium tuberculosis activity of compounds from Cedrela fissilis Vell. Seeds (Meliaceae)

Abstract

The phytochemistry of the species Cedrela fissilis Vell., family Meliaceae, also popularly known as “cedro rosa”, was investigated, leading to the isolation of four compounds from the crude methanolic extract of its seeds; the triterpene Piscidinol A (1), and three limonoids, Andirolide N (2), Mexicanolide (3), and Proceranolide (4). Subsequently, the antimycobacterial, anti-inflammatory, and cytotoxicity activities of these compounds were investigated. The Proceranolide limonoid (4) presented the best result for the investigated biological activities, with moderate antimycobacterial activity, considerable inhibition of nitric oxide production, and low cytotoxicity. The Andirolide N (2) and Proceranolide (4) limonoids are being reported for the first time in the Cedrela genus.