ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

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Abstract

Lack of FMRP in Fragile X neurons is associated with a leak in the ATP synthase, the blockade of which normalizes cellular and behavioral disease phenotypes.

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Licznerski, P., Park, H. A., Rolyan, H., Chen, R., Mnatsakanyan, N., Miranda, P., … Jonas, E. A. (2020). ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome. Cell, 182(5), 1170-1185.e9. https://doi.org/10.1016/j.cell.2020.07.008

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