The recruitment of AMP-activated protein kinase to glycogen is regulated by autophosphorylation

Abstract

Background: AMP-activated protein kinase (AMPK) is a current drug target. AMPK can attach to glycogen granules. Results: Autophosphorylation of AMPK prevents its association with glycogen. Conclusion: Subcellular localization of AMPK is affected by the kinase autophosphorylation status. Significance: Understanding the regulation of AMPK at subcellular level is crucial for the currently pursued drug targeting approach.