Catalytic, enantioselective synthesis of Boc-protected 1,2-amino alcohols through aminolysis of meso-epoxides with benzophenone imine

Abstract

Aromatic meso-epoxides 3 have been ring-opened with benzophenone imine (2) using catalytic quantities of the chiral scandium bipyridine complex 1a to furnish Boc-protected 1,2-amino alcohols 5 in good yields and enantioselectivities after acidic hydrolysis and Boc-protection. © ARKAT USA, Inc.