The susceptibility to penicillin of 111 Neisseria meningitidis strains was assessed by the agar-dilution procedure and serosubtypes were determined by a whole-cell enzyme-linked immunoassay using monoclonal antibodies reagents. Thirty-five isolates showed reduced sensitivity to penicillin (MIC ≥ 0.1 mg/l and ≤ 1 mg/l) and no resistant strains were detected. The most common phenotype was B:4:P1.15 (77.5%) and a rising trend of non-typeable and non-subtypeable strains was detected. The increase in levels of minimal inhibitory concentrations of meningococci to penicillin gives cause for concern and the increase in non-typeable and non-subtypeable isolation demand the use of molecular biology techniques for their typing.
CITATION STYLE
Sosa, J., Llanes, R., Guzmán, D., Quintana, I., Flores, M., & Gutiérrez, O. (2001). Typing and Susceptibility to Penicillin of Neisseria meningitidis Isolated from Patients in Cuba (1993-1999). Memorias Do Instituto Oswaldo Cruz, 96(4), 523–525. https://doi.org/10.1590/S0074-02762001000400014
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