1024 Comparison Of Sleep Actigraphy Between Normal Participants And Patients Of Parkinson’S Disease

Abstract

Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor symptoms, and sleep disturbance is one of the most prevalent nonmotor symptom of PD. The aim of the present study is to compare the objectively measured sleep quality between normal participants and PD patients. Method(s): Of all 1127 participants of the HEIJO-KYO study, a community based cohort study among elderly, we excluded 10 participants due to incomplete sleep actigraphy and 9 participants with medication for PD, and 1108 normal participants were remained for analysis. We recruited 156 PD patients diagnosed by neurologist at Nara Medical University hospital and surrounding hospitals. All patients were divided into early PD (Hoehn and Yahr stage 1-2) and late PD (stage 3-4). Sleep quality was measured for consecutive 2 nights among normal participants, and 7 nights among PD patients using actigraphy (Actiwatch 2, Respironics Inc) worn in non-dominant arm. Sleep parameters of normal participants were calculated using validated setting with activity threshold of 40 with 5 immobile min, and those of PD patients were calculated using validated activity threshold of 10 with 5 immobile min. Result(s): Mean age was 71.9 (SD: 7.1) years among normal patients, and 71.3 (7.7) years among PD patients. PD patients consisted of early PD (n=95) and late PD (n=61). Compared with normal participants, early and late PD patients showed significantly shorter total sleep time (TST: 420.3 min vs. 351.9 min, 321.6 min, p for trend <0.01), lower sleep efficiency (SE: 84.7% vs. 74.6%, 67.4%, p for trend <0.01), longer wake after sleep onset (WASO: 57.3 min vs. 92.1 min, 119.1 min, p for trend <0.01) and shorter sleep onset latency (SOL: 10.5 min vs. 8.0 min, 8.0 min, p for trend <0.01). These association remained significant after adjustment for confounders such as age, gender, body mass index, current smoking, drinking, insomnia medication, and education length. Conclusion(s): Sleep actigraphy among PD patients showed shorter TST, lower SE and longer WASO, but shorter SOL than normal participants.