The myxovirescins a family of antibiotics from myxococcus virescens (myxobacterales)

Abstract

The myxobacterium, Myxococcus virescens strain Mx v48 produced a family of at least 12 closely related antibiotics, the myxovirescins***. At a concentration of 1 to 5μg/ml, the main component, myxovirescin A, was bactericidal for many Gram-negative bacteria, in particular enterobacteria, and at 20 to 50 μg/ml it also inhibited some pseudomonads and Gram-positive bacteria. The antibiotics seem to interfere with cell wall synthesis. The molecular formula of myxovirescin A was C35H61NO8 It is a new antibiotic. © 1982, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.