The myxalamids, new antibiotics from myxococcus xanthus (myxobacterales) I. production, physico-chemical and biological properties, and mechanism of action

Abstract

From the cell mass and culture supernatant of Myxococcus xanthus strain Mx X12 an antibiotic activity against yeasts, molds and some Gram-positive bacteria could be extracted. It consisted of 4 biologically active compounds which were named myxalamid A, B, C and D. The main component, myxalamid B, was shown to block in beef heart submitochondrial particles the respiratory chain at the site of complex I, i.e. NADH: ubiquinone oxidoreductase. The myxalamids are new antibiotics. © 1983, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.