Copper-mediated regioselective allylation and propargylation of 2-(alkylthio)oxazoles

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Abstract

Copper-mediated regioselective allylation and propargylation of 2-(n-butylthio)oxazole at the C5-position provided 2,5-disubstituted oxazoles in moderate to good yields. Subsequent removal of the n-butylthio group with deactivated W2-Raney nickel gave 5-substituted oxazoles. © 2003 Elsevier Ltd. All rights reserved.

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Marino, J. P., & Nguyen, H. N. (2003). Copper-mediated regioselective allylation and propargylation of 2-(alkylthio)oxazoles. Tetrahedron Letters, 44(40), 7395–7398. https://doi.org/10.1016/j.tetlet.2003.08.044

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