Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery

Abstract

Background: The aim of the present study was to evaluate clinical efficacy of constant rate infusions (CRIs) of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery. Thirty horses were sedated intravenously (IV) with medetomidine (6.0μg/kg) and midazolam (0.02mg/kg) and induced IV with ketamine (1.0mg/kg) and propofol (1.0mg/kg). These horses were randomly allocated to three groups and maintained with sevoflurane and CRI of either medetomidine (3.0μg/kg/h) (Group M; n=10); or medetomidine (3.0μg/kg/h) and propofol (3.0mg/kg/h) (Group MP3; n=10); or medetomidine (3.0μg/kg/h) and propofol (6.0mg/kg/h) (Group MP6; n=10). End-tidal sevoflurane concentration (ETSEVO), cardiovascular parameters, plasma propofol concentration, and recovery time and quality were compared among groups. Data were analyzed by using ANOVA with Tukey's multiple comparison test, considering P<0.05 significant. Results: ETSEVO (%) was 2.4±0.1 in Group M, 1.7±0.2 in Group MP3, and 1.4±0.2 in Group MP6; ETSEVO declined significantly in a propofol-dose-dependent manner. The rates of dobutamine infusion (μg/kg/min) required to keep the mean arterial blood pressure over 70mmHg were significantly lower in Group MP3 (0.20±0.10) and Group MP6 (0.15±0.06) than in Group M (0.37±0.18). Recovery time and quality did not differ among groups. All horses in Group MP3 required only one attempt to stand, and recovery quality was excellent. Plasma propofol concentrations were stable throughout maintenance of anesthesia in Group MP3, whereas those in Group MP6 increased significantly with increasing duration of maintenance. Conclusions: CRIs of medetomidine-propofol reduced the sevoflurane requirement for surgical anesthesia as the propofol dose increased, compared with a CRI of medetomidine alone. Additionally, the two propofol protocols provided good maintenance of cardiovascular function. CRIs of medetomidine (3.0μg/kg/h) and propofol (3.0mg/kg/h) resulted in excellent-quality recovery. This protocol could therefore be an especially useful additive to sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery.