Pharmacokinetics of protein c and antithrombin in the fetal Lamb: A model to predict human neonatal replacement dosing

Abstract

Background: The preterm infant is at risk for consumptive coagulopathy and thrombosis du: 3.86 h (95% CI: 3.35-4.36) and 11.9 h (95% CI: 10.9-12.9) in the singletons and ewes, respectively. All PC parameters were significantly different for twins compared to ewes. Conclusions: AT and PC show decreased recovery and t in the fetal lamb. These data can be used to estimate dosing for human neonates in comparison with human adult dosing recommendations. Copyright © 2008 S. Karger AG, Basel.