Advances in the Synthetic Utility of Difluorocarbene Generated from TMSCF3 (Ruppert-Prakash Reagent) and Its Derivatives

Abstract

Organofluorine compounds are of pivotal significance particularly, in drug and agrochemical industries and different strategies have been designed for their synthesis. The last two decades witnessed the emergence of difluorocarbene as an efficient synthetic tool, providing easy access to organofluorine compounds. This review summarises the reactions of difluorocarbene generated from Ruppert-Prakash reagent (TMSCF3) and its derivatives TMSCF2Cl and TMSCF2Br. Among the various fluorination techniques available, the difluorocarbene chemistry offers a cost effective and easy procedure, opening avenue to a large number of organofluorine compounds. This review details the developments in the utility of difluorocarbene generated from TMSCF3 and its derivatives, till date.