Metallophore mapping in complex matrices by metal isotope coded profiling of organic ligands

Abstract

Metal isotope coded profiling (MICP) introduces a universal discovery platform for metal chelating natural products that act as metallophores, ion buffers or sequestering agents. The detection of cation and oxoanion complexing ligands is facilitated by the identification of unique isotopic signatures created by the application of isotopically pure metals. © 2014 the Partner Organisations.