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FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer

Molecular and Cellular Oncology (2016) 3(3)
DOI: 10.1080/23723556.2015.1131668
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Abstract

The Forkhead box C1 (FOXC1) transcriptional factor is a critical biomarker for basal-like breast cancer (BLBC). We recently reported that FOXC1 promotes cancer stem cell properties in BLBC by activating Smoothened (SMO)-independent Hedgehog (Hh) signaling, suggesting a FOXC1-mediated mechanism for BLBC cell function and anti-Hh therapy resistance.

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Han, B., Qu, Y., Yu-Rice, Y., Johnson, J., & Cui, X. (2016). FOXC1-induced Gli2 activation: A non-canonical pathway contributing to stemness and anti-Hedgehog resistance in basal-like breast cancer. Molecular and Cellular Oncology, 3(3). https://doi.org/10.1080/23723556.2015.1131668

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