Prevention of peritoneal dialysis-related peritonitis by regular patient retraining via technique inspection or oral education: A randomized controlled trial

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Abstract

Background: There has been little research on strategies for prevention of peritoneal dialysis (PD)-related peritonitis. We explored whether regular retraining on bag exchanges (via two methods: technique inspection and oral education) every other month could help reduce the risk of peritonitis in PD patients through a randomized controlled trial (RCT). Method: This is an RCT conducted at Peking University First Hospital. A total of 150 incident patients receiving PD at our centre were included between December 2010 and June 2016 and followed up until June 2018. Patients were randomly assigned 1:1:1 to receive retraining on bag exchange via technique inspection, oral education or usual care. The primary outcome was time to the first peritonitis episode. Secondary outcomes were time to organism-specific peritonitis, transfer to haemodialysis and all-cause death. Results: Patients in the technique inspection group, oral education group and usual care group (n = 50 for each group) were followed up for 47.5 ± 22.9 months. Time to first peritonitis was comparable between the groups. The technique inspection group showed a lower risk of first non-enteric peritonitis than the usual care group, while the oral education group did not show a significant benefit. The incidence of first non-enteric peritonitis in the usual care group (0.07/patient-year) was significantly higher than that in the technique inspection group (0.02/patient-year; P < 0.01) but was comparable with that in the oral education group (0.06/patient-year). Transfer to haemodialysis and all-cause mortality were not significantly different between the groups. Conclusions: Neither technique inspection nor oral education significantly altered the risk of all-cause peritonitis compared with usual care, despite technique inspection showing a trend towards reducing the risk of non-enteric PD-related peritonitis. Trial registration: ClinicalTrials.gov (NCT01621997).

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Xu, Y., Zhang, Y., Yang, B., Luo, S., Yang, Z., Johnson, D. W., & Dong, J. (2020). Prevention of peritoneal dialysis-related peritonitis by regular patient retraining via technique inspection or oral education: A randomized controlled trial. Nephrology Dialysis Transplantation, 35(4), 676–686. https://doi.org/10.1093/ndt/gfz238

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