Pattern Visual Evoked Potential (VEP) is Unaffected in the Early Stage of Mild Cognitive Impairment

Abstract

The aim of this study was to determine whether pattern-reversal Visual Evoked Potential (PRVEP) is affected in mild cognitive impairment (MCI). Participants aged ≥ 60 years diagnosed as MCI were invited to participate in a study together with a group of controls. PRVEP was measured using A RETI-port/Scan 21 and stimuli of large and small checks sizes, 1° (60 min of arc) and 0.25° (15 min) respectively were used to obtain responses. The amplitude and implicit times of the MCI and control groups were then compared. A total of 18 MCI participants (age 65.7 ± 3.1 years) and 18 controls (65.1 ± 3.8 years) consented to participate in the study. The amplitude and implicit times for the MCI group using the target sizes of 60 min of arc were 9.80 ± 4.06 µV and 108.83 ± 7.63 ms and for 30 min of arc were 11.00 ± 7.44 µV and 123.96 ± 6.18 ms respectively. Consecutively for the control groups the amplitudes and implicit times were 8.96 ± 3.52µV, 105.85 ± 3.60 ms and 11.97± 6.11 µV, 122.57 ± 8.28 ms. PRVEP results did not reveal significant differences in P100-wave amplitude nor implicit time between the two groups under investigation. This study concluded that the visual pathway