Abstract
We describe the extension of a computational model of blood flow and metabolism in the piglet brain to investigate changes in neonatal intracellular brain pH during hypoxia-ischemia (HI). The model is able to simulate near-infrared spectroscopy (NIRS) and magnetic resonance spectroscopy (MRS) measurements obtained from HI experiments conducted in piglets. We adopt a method of using 31 P-MRS data to estimate of intracellular pH and compare measured pH and oxygenation with their modelled counterparts. We show that both NIRS and MRS measurements are predicted well in the new version of the model. © 2013 Springer Science+Business Media New York.
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CITATION STYLE
Hapuarachchi, T., Moroz, T., Bainbridge, A., Price, D., Cady, E., Baer, E., … Tachtsidis, I. (2013). Modelling blood flow and metabolism in the piglet brain during hypoxia-ischaemia: Simulating pH changes. In Advances in Experimental Medicine and Biology (Vol. 789, pp. 331–334). Springer New York LLC. https://doi.org/10.1007/978-1-4614-7411-1_44
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