Enantiomeric separation of drugs and herbicides on a β-cyclodextrin-bonded stationary phase

Abstract

A chemically bonded β-cyclodextrin chiral stationary phase for HPLC was prepared in a "one pot" process by the reaction of a phenylated β-cyclodextrin with silica gel. Various racemic analytes such as drugs (aminoalcohol adrenergic β-blockers, benzodiazepine anxiolytics, arylpropionic acid antiinflammatory agents) and herbicides (aryloxypropionic acids and esters) were separated on the prepared material. The column showed good chiral recognition ability for most of the solutes tested when using heptane and either 2-propanol or chloroform as organic mobile phase modifiers. © 2002 Wiley-Liss, Inc.