HER2 joins AKT to inhibit STING immunity

Abstract

Activation of the receptor EGFR (ERBB1) occurs in response to viral infections and regulates antiviral immunity. A new study now shows that the receptor HER2 (ERBB2) negatively regulates STING signaling in response to DNA viruses and expands the model and mechanisms by which surface-receptor tyrosine kinases perform important intracellular regulatory functions.