Oral gabapentin reduces respiratory rate and resistance scores in adult domestic pigeons (Columba livia domestica) during and after handling

Abstract

Objective To determine whether a single oral dose of gabapentin would generate any changes in heart rate or respiratory rate or behaviors during and after handling of adult domestic pigeons (Columba livia domestica). Methods Pigeons were housed alone on the day of the study but were otherwise group housed throughout the 9-day study period. Pigeons were assessed before handling and at 1 and 2 hours posttreatment. Behaviors (resting, aggressive, reactionary, maintenance, and feeding behaviors) and physiologic parameters were evaluated before, during, and after handling at each time point. A modified human intruder test, sedation score, and resistance score were developed and compared between time points. Results As part of a blinded, randomized, crossover study, 20 pigeons received 50 mg/kg of oral gabapentin or an equal volume of tap water (control) with an 8-day washout period. Respiratory rates were significantly higher in the control group at 2 hours during the intruder test and at 1 and 2 hours posttreatment in the period following the exam. Resistance scores were significantly higher in the control group at 2 hours posttreatment during handling. There was no significant difference in heart rates or behaviors. Four pigeons exhibited mild sedation after gabapentin administration. No major adverse effects were observed. Conclusions Gabapentin administered orally at 50 mg/kg to pigeons decreased respiratory rates and resistance scores during and after examinations for up to 2 hours. Mild sedation was the only adverse effect observed. Clinical Relevance Oral gabapentin may be beneficial when handling pigeons and may reduce stress associated with handling.