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Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

Antimicrobial Agents and Chemotherapy (2004) 48(9) 3552-3555
DOI: 10.1128/AAC.48.9.3552-3555.2004
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Abstract

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence of this mutation in patients failing nelfanavir-based regimens.

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Gonzalez, L. M. F., Brindeiro, R. M., Aguiar, R. S., Pereira, H. S., Abreu, C. M., Soares, M. A., & Tanuri, A. (2004). Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases. Antimicrobial Agents and Chemotherapy, 48(9), 3552–3555. https://doi.org/10.1128/AAC.48.9.3552-3555.2004

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