Mitochondrial biology in reproduction

Abstract

Mitochondrial biology plays an important role in the reproductive process, with influence on germ cell development and quality as well as embryonic development and reproductive success. This review outlines the role of mitochondrial genetics and function in reproductive biology, including a discussion of general mitochondrial function, genetics and germline transmission. Also highlighted are the mitochondrial morphologic changes that occur during oogenesis and the role these changes play in the mitochondrial bottleneck that influences the distribution of deleterious mitochondrial genomes to offspring. The review covers the influence of mitochondria in embryonic stem cell and induced pluripotent stem cell biology and development. Lastly, the role of mitochondrial biology in assisted reproductive techniques is discussed. © Japan Society for Reproductive Medicine 2011.