BIOACTIVE COMPONENTS AND ANTIOXIDANT, ANTIPROLIFERATIVE, AND ANTIHYPERGLYCEMIC ACTIVITIES OF WILD CORNELIAN CHERRY (CORNUS MAS L.)

Abstract

The contents of polyphenolic components (total polyphenols, flavonoids, and monomeric anthocyanins) and vitamin C, and the bioactive potential (antioxidant, antiproliferative, and antihyperglycemic activities) of wild cornelian cherry were determined. Samples were collected from four different locations in Bosnia and Herzegovina. Sample CC3 from Drinic had the highest monomeric anthocyanin content (1.40 mg CyGE/g FW) and the highest inhibition of free radicals (IC50DPPH = 262.19 mg/ml; IC50ABTS = 76.78 mg/ml; IC50OH' = 102.31 mg/ml) and inhibition of breast adenocarcinoma cell line growth (IC50MCF-7 = 1.37 mg/ml). Sample CC4 from Drvar showed the highest total polyphenol (55.92 mg GAE/g DW) and vitamin C (88.74 mg/g FW) contents. Sample CC4 significantly inhibited the growth of cervix epithelioid carcinoma (IC50HeLa = 0.62 mg/ml) and lung adenocarcinoma (IC50A549 = 0.48 mg/ml) cell lines, and a-glucosidase (IC50AGHA = 0.466 mg/ml). Wild cornelian cherry could be used as a functional food with beneficial pro-health properties.