Synthesis and Antibacterial Studies of Some Reduced Schiff Base Derivatives

Abstract

A series of N,N-substituted ethylene-1,2-diamine derivatives have been prepared from reaction of 2-hydroxybenzaldehyde derivatives and 1,2-diamine derivatives in the presence of NaBH4 through Schiff base intermediate. The synthesized compounds were screened for their antibacterial activities. Compound SB01, SB02 and SB09 displayed significant activity at MIC ranges from 0.40-6.25 µg/mL.