SCUBE3 (signal peptide-cub-egf domain-containing protein 3) modulates fibroblast growth factor signaling during fast muscle development

Abstract

Background: Function and signaling mediated by SCUBE3 during development remain poorly understood. Results: Loss and gain of function studies showed that SCUBE3 could modulate FGF8 signal activity for fast muscle development. Conclusion: scube3 is critical for and acts at top of the regulatory hierarchy of fast fiber myogenesis by enhancing fgf8 signaling. Significance: Scube3 is a key regulator for fast muscle development in vertebrates. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.