The association of air pollution with birthweight and gestational age: Evidence from Hong Kong's 'Children of 1997' birth cohort

Abstract

Background Previous studies from Western settings have found inconsistent associations of air pollutants with birth outcomes, which are open to residual confounding by socioeconomic position (SEP). We assessed this association in the economically developed non-Western setting of Hong Kong, with high levels of air pollution but little social patterning of these outcomes. Methods We obtained PM10, SO2, NO and NO2 from monitoring stations, and assessed their associations with birthweight and gestational age in a large population-representative birth cohort 'Children of 1997', using partial least-square regression to account for the colinearity between pollutants. Results PM10 (per 5.7 µg/m3 higher) and NO2 (per 10.9 µg/m3 higher) were associated with birthweight lower by 47.0 g (95% confidence interval (CI) 36.2-56.3) and 16.9 g (95% CI 10.8-22.6), respectively; and were associated with gestational age shorter by 2.1 days (95% CI 1.7-2.4) and 0.7 days (95% CI 0.5-0.8), respectively. Conclusions Given minimal confounding by SEP in our setting, these findings provide unequivocal evidence of adverse effects of PM10 and NO2 exposure during pregnancy on birthweight and gestational age. Physiological mechanisms need to be better understood to support effective public health action globally.